Not known Factual Statements About rheumatoid arthritis test


The immune system of a lot of people is failing to distinguish between healthy cells and invader micro-organisms. This is creating more suffering across the globe. Instead of protecting themselves from illness the organs and tissues are being attacked by these same defenses.




A major international effort in research is underway to stop this trend. A London-based organization called the Francis Crick Institute, has two world experts, James Lee & Carola Vinuesa created separate research teams to figure out the exact causes of the autoimmune condition.


Lee explained to the Observer that the occurrence of autoimmune diseases began to rise around 40 years ago in western nations. But, some of these cases are now occurring in countries that have never experienced such diseases.


For instance the Middle East/East Asia has seen the largest recent increase in inflammatory-bowel disease cases. They had never before seen the disease.


Type 1 diabetes may be caused by rheumatoid arthritis and multiple sclerosis. In each of these cases, the immune system gets its wires crossed, and it turns on healthy tissue instead of the infectious agents.


These conditions have been reported by as many as 4 million people living in the UK. A few sufferers could suffer from multiple. In the world, it is believed that the number of cases of autoimmune disease is increasing by between 3 and 9 percent each year. This rise is believed to be caused by environmental factors, according to the majority of scientists.


Lee, who was previously based in Cambridge University, stated that genetics has not changed over recent years. There must be something outside that is causing our predisposition for autoimmune disease.


Vinuesa who used to be located at the Australian National University, endorsed the concept. She outlined the shifts in the way people eat as more nations adopt western eating patterns and people consumed more fast food.


Vinuesa states that many fast-food meals lack vital ingredients, such as fibre. The change could affect your microbiome, which is the collection micro-organisms present in our bodies which play an important function in controlling various bodily functions.


Changes in microbiomes can then trigger autoimmune diseases. More than 100 types of autoimmune diseases have been discovered.


Both scientists stressed the fact that every person is susceptible to developing these illnesses, which include celiac, Lupus, and other conditions, such as celiac, that cause swelling and inflammation and can cause serious harm to different organs.


Vinuesa claims that anyone who doesn't have a specific genetic susceptibility will not get an autoimmune disease regardless of the amount of Big Macs they consume. "There isn't anything we can do to slow the spread of fast food franchises. Instead, we are trying to unravel the genetic factors that lead to the autoimmune diseases that make certain individuals susceptible, while others are not. This is the way we intend to solve the problem."


With the help of modern technology, scientists can now pinpoint small Read More differences in DNA between large numbers of individuals. It is possible to determine common genetic patterns between those with an autoimmune disorder.


Lee explained that the ability to sequence huge amounts of DNA has transformed the entire process. We didn't have these tools until the last few years. My study revealed that there are about six DNA variations that are involved in the triggering of inflammatory bowel disease. We now have over 250.


Lee and Vinuesa are pursuing these kinds of research because they want to learn more about how genetic pathways work and what causes the different illnesses that doctors are currently looking into. Vinuesa said that autoimmune diseases such as Lupus, for instance, can be seen in many forms, and may have different genetic causes. This is a problem when you are trying to determine the best treatment.


There are a lot of new therapies that are likely to be beneficial, but we don’t have the appropriate patients. Actually we do not have the necessary information to know if these patients suffer from the same condition. This is the purpose of research into autoimmune diseases. In order to provide the appropriate treatment, we must learn how to categorize patients.


Lee explained that the increasing incidence of autoimmune diseases around the world means new medications and treatments are needed now more than ever before. Lee said there was at present no treatment for autoimmune diseases. They typically occur in young people when they are trying to finish their education, find a job, and start families.


This means that more patients are scheduled for surgery or be required to receive regular injections for the remainder of their lives. It's a bleak time for patients and a massive burden on health care services. So, it is essential to find effective and new treatment options.


Rheumatoid Arthritis is an autoimmune condition, which means it's due to the immune system attacking healthy body tissue. However, we aren't sure what triggers it.


The immune system typically produces antibodies that attack viruses and bacteria, helping to fight infections.


If you have Rheumatoid Arthritis, your immune system is sending antibodies to the joint's lining which attack the tissues surrounding the joint.


The thin layer (synovium) that is a protective layer on your joints, can be inflamed and inflamed which releases chemicals and cause damage.


bones

cartilage - the stretchy connective tissue between bones

Tendons - The tissue that connects bone and muscle

Ligaments The ligaments are the tissues that connects bones and cartilage.

Rheumatoid arthritis may be treated but not controlled. The chemicals that cause it make the joint unbalanced and distorted. These chemicals could eventually cause the destruction of the joint in its entirety.


Various theories of how the immune system can Check out attack the joints have been suggested including an infection as the trigger, but none of these theories have been proven.


Possible risk factors



You could be more at the risk of developing rheumatoidarthritis when you perform the following:


the genes you carry - there's evidence to suggest that arthritis may be passed down through families, but the likelihood of passing it on is thought to be low because genes are thought to play a minor influence on the condition.

hormones. Rheumatoid arthritis is more prevalent in women than in men. This could be due to the effects of the hormone oestrogen, although this link has not been proved

Smoking cigarettes is a risk cause for rheumatoid artifiid. There is evidence to support this.

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